Silica nanoparticles from burning sugarcane and rice husks may cause chronic kidney disease in laborers worldwide, says new study in El Salvador.

Researchers are currently investigating the potential link between the practice of burning sugarcane and the widespread incidence of a mystery kidney disease among agricultural workers.

In recent decades, various parts of the global agricultural community have been struck with a puzzling kidney disease. This ailment, often referred to as chronic kidney disease of undetermined causes (CKDu), affects agricultural workers predominantly.

As the name suggests, a definitive cause for the disease has remained elusive. However, researchers have found a potential link tracing back to the practice of burning sugarcane, a task that a significant proportion of agricultural workers are exposed to.

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Sugarcane agribusinesses typically set fields ablaze before the harvest. This burning process is employed to get rid of the excess, non-profitable biomass, leaving only the sugarcane that can be harvested for sugar production.

Silica nanoparticles from burning sugarcane and rice husks may cause chronic kidney disease in laborers worldwide, says new study in El Salvador. ImageAlt

This technique, while efficient for the industry, subjects workers to exposure to high levels of pollutants. These pollutants, including smoke and ash, are released into the air the workers breathe and can have potentially harmful effects on their health.

The University of Colorado Anschutz Medical Campus conducted a study which suggests that exposure to these pollutants from the burning of sugarcane is a possible cause of CKDu among workers. This research represents an important development in the fight against this elusive disease.

The researchers from Anschutz Medical Campus studied the prevalence of CKDu among Nicaraguan sugarcane workers. Nicaragua, a major global producer of sugarcane, has a reported high incidence of CKDu among its agricultural workers. This correlation made it an optimal location for the study.

The team analyzed the correlation between the exposure to the sugarcane burning residues and the development of CKDu. They employed a range of methods, including various animal models and human subject research, to obtain vital findings.

Among the results obtained, it was discovered that mice exposed to sugarcane burning smoke exhibited significantly higher instances of kidney damage than their counterparts who were not. This indicated a potential causal relationship between the two factors.

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On the human side of the research, the researchers supported these findings observing similar trends. Sugarcane workers exposed to burning residues exhibited much higher levels of a kidney-damage biomarker. This disturbing trend was not registered in control groups consisting of workers who carried out sugarcane-related tasks but were not exposed to the harmful smoke and ash.

In addition to this correlation, the research also unveiled a possible mechanistic pathway related to the smoke's harmful effects on the kidneys. It was found that the air pollutants from the sugarcane burning led to cellular inflammation and death, mechanisms known to cause kidney injury.

This revelation of a possible physical pathway linking the exposure to pollutant and subsequent kidney damage provides a rational explanation for the high cases of CKDu. It provides a foundation to build upon in future research to fully unravel the elusive disease.

The Anschutz Medical Campus research is significant. It has laid groundwork for a plausible explanation for the high instances of CKDu among sugarcane workers. Given this relationship, the industry and legislators must reevaluate the practice of burning sugarcane.

To take effective action against this harmful practice, governments and organizations worldwide must be sensitized to the potential human costs. Workers' health and wellness must be prioritized, even if it means the industry bears additional operational costs.

The agricultural industry, especially those involved in sugarcane production, should invest in researching alternative methods to the open burning of sugarcane that could be less harmful to the workers. Agriculture is a vital sector; however, its continuity should not come at the cost of its workers' health.

While this research offers valuable insight into the potential cause of CKDu, it also highlights the broader issue of occupational health hazards in the agricultural industry. These concerns must be brought to the forefront, and the protection of those who work tirelessly in our fields should be non-negotiable.

Lastly, it is critical not to overlook the broader implications of the burning of sugarcane. Aside from the potential health risks to workers, this method of preparing sugarcane fields contributes substantially to air pollution and has a negative impact on climate change.

Through definitive research, sound policy changes and thorough implementation, this research's findings can make a substantial positive impact. Protecting agricultural workers, creating more sustainable farming practices and mitigating climate change impacts are all potential benefits of reevaluating our agricultural practices.

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